Calcium Phosphate Microcapsules as Multifunctional Drug Delivery Devices

More challenging active pharmaceutical ingredients are entering the market, spurring introduction of novel drug delivery strategies that necessitate a paradigm shift from exhausted excipients to materials with combined actions and multiple functionalities. In this study, an inorganic calcium phosphate microparticle hollow internal structure is introduced as biocompatible multifunctional microcapsule: template inverted particle (TIP). A robust process presented create unique geometry, which characterized by size 20 µm cavity enclosed specially engineered porous shell. This study focuses on characterization TIP excipient for design solid dosage forms. The cavities in centers serve encapsulation space, resulting boosted water uptake capacity 5.3 cm3 g−1. Benefiting material's high wettability rates, tablets immediately disperse oral cavity. Mechanistic studies reveal viscoelastic behavior empty microcapsules accordance Kelvin–Voigt model parallel spring-dashpot configuration. geometry maintained during compaction thanks its exceptional structural integrity. demonstrates how can be applied device.